| Number | @name | Name | Followers | Influence Rank |
| 1 | @mashable | Pete Cashmore | 2037840 | 59 |
| 2 | @cnnbrk | CNN Breaking News | 3224475 | 71 |
| 3 | @big_picture | The Big Picture | 23666 | 92 |
| 4 | @theonion | The Onion | 2289939 | 116 |
| 5 | @time | TIME.com | 2111832 | 143 |
| 6 | @breakingnews | Breaking News | 1795976 | 147 |
| 7 | @bbcbreaking | BBC Breaking News | 509756 | 168 |
| 8 | @espn | ESPN | 572577 | 187 |
| 9 | @harvardbiz | Harvard Business Rev | 219039 | 227 |
| 10 | @gizmodo | Gizmodo | 111025 | 237 |
| 11 | @techcrunch | TechCrunch | 1402254 | 319 |
| 12 | @wired | Wired | 547187 | 322 |
| 13 | @wsj | Wall Street Journal | 366133 | 358 |
| 14 | @smashingmag | Smashing Magazine | 224333 | 360 |
| 15 | @pitchforkmedia | Pitchfork | 1494896 | 384 |
| 16 | @rollingstone | Rolling Stone | 133999 | 436 |
| 17 | @whitehouse | The White House | 1794544 | 448 |
| 18 | @cnn | CNN | 1196719 | 473 |
| 19 | @tweetmeme | TweetMeme | 52386 | 515 |
| 20 | @peoplemag | People magazine | 2099081 | 565 |
| 21 | @natgeosociety | National Geographic | 274851 | 603 |
| 22 | @nytimes | The New York Times | 2502914 | 705 |
| 23 | @lifehacker | Lifehacker | 62302 | 708 |
| 24 | @foxnews | Fox News | 260081 | 710 |
| 25 | @waitwait | waitwait | 32895 | 824 |
| 26 | @newsweek | Newsweek | 1250884 | 844 |
| 27 | @huffingtonpost | Huffington Post | 632555 | 849 |
| 28 | @newscientist | New Scientist | 144355 | 852 |
| 29 | @mental_floss | Mental Floss | 68975 | 874 |
| 30 | @theeconomist | The Economist | 311109 | 902 |
| 31 | @emarketer | eMarketer | 30235 | 906 |
| 32 | @engadget | Engadget | 135418 | 999 |
| 33 | @cracked | Cracked.com | 110611 | 1037 |
| 34 | @slate | Slate | 71091 | 1040 |
| 35 | @bbcclick | BBC Click | 1749470 | 1041 |
| 36 | @fastcompany | Fast Company | 148292 | 1056 |
| 37 | @reuters | Reuters Top News | 194429 | 1119 |
| 38 | @incmagazine | Inc. Magazine | 109256 | 1143 |
| 39 | @eonline | E! Online | 2271026 | 1227 |
| 40 | @rww | Richard MacManus | 1037907 | 1232 |
| 41 | @gdgt | gdgt | 20556 | 1315 |
| 42 | @instyle | InStyle | 1716786 | 1330 |
| 43 | @mckquarterly | McKinsey Quarterly | 90981 | 1354 |
| 44 | @enews | E! News | 279737 | 1540 |
| 45 | @nprnews | NPR News | 270561 | 1572 |
| 46 | @usatoday | USA TODAY Top News | 62790 | 1628 |
| 47 | @mtv | MTV | 648014 | 1714 |
| 48 | @freakonomics | freakonomics | 124751 | 1784 |
| 49 | @boingboing | Boing Boing | 48649 | 1811 |
| 50 | @billboarddotcom | Billboard.com | 63766 | 1818 |
| 51 | @empiremagazine | Empire Magazine | 33335 | 1905 |
| 52 | @todayshow | The Today Show | 620413 | 1927 |
| 53 | @good | GOOD | 414956 | 2003 |
| 54 | @gawker | Gawker | 37980 | 2027 |
| 55 | @msnbc_breaking | msnbc Breaking News | 59375 | 2088 |
| 56 | @cbsnews | CBS News | 1575638 | 2090 |
| 57 | @guardiantech | Guardian Tech | 1592067 | 2139 |
| 58 | @usweekly | Us Weekly | 228728 | 2233 |
| 59 | @life | LIFE.com | 1270303 | 2277 |
| 60 | @sciam | Scientific American | 88336 | 2373 |
| 61 | @pastemagazine | Paste Magazine | 64642 | 2379 |
| 62 | @drudge_report | Drudge Report | 100558 | 2468 |
| 63 | @parisreview | The Paris Review | 22127 | 2599 |
| 64 | @latimes | Los Angeles Times | 71287 | 2625 |
| 65 | @telegraphnews | Daily Telegraph News | 17325 | 2629 |
| 66 | @abc7 | ABC7 Eyewitness News | 36343 | 2638 |
| 67 | @arstechnica | Ars Technica | 82051 | 2692 |
| 68 | @cnnmoney | CNNMoney.com | 219552 | 2777 |
| 69 | @nprpolitics | NPR Politics | 1801871 | 2882 |
| 70 | @nytimesphoto | New York Times Photo | 79443 | 2927 |
| 71 | @nybooks | NY Review of Books | 89827 | 2966 |
| 72 | @nielsenwire | Nielsen Wire | 13840 | 2994 |
| 73 | @io9 | io9 | 12152 | 3023 |
| 74 | @sciencechannel | Science Channel | 82514 | 3064 |
| 75 | @usabreakingnews | USA Breaking News | 13987 | 3120 |
| 76 | @vanityfairmag | VANITY FAIR | 76282 | 3182 |
| 77 | @cw_network | CW Network | 70031 | 3183 |
| 78 | @bbcworld | BBC World News | 262857 | 3202 |
| 79 | @abc | ABCNews.com | 1119958 | 3411 |
| 80 | @themoment | The Moment | 1580569 | 3413 |
| 81 | @socialmedia2day | Social Media Today | 34516 | 3510 |
| 82 | @slashdot | Slashdot | 29011 | 3527 |
| 83 | @washingtonpost | The Washington Post | 149617 | 3636 |
| 84 | @tpmmedia | Talking Points Memo | 15438 | 3678 |
| 85 | @msnbc | msnbc.com | 41155 | 3696 |
| 86 | @wnycradiolab | Radiolab | 9591 | 3776 |
| 87 | @cnnlive | CNN Live | 39260 | 3793 |
| 88 | @davos | World Economic Forum | 1508772 | 3891 |
| 89 | @planetmoney | NPR's Planet Money | 81309 | 3965 |
| 90 | @cnetnews | CNET News.com | 75730 | 3981 |
| 91 | @politico | POLITICO | 83729 | 4048 |
| 92 | @tvnewser | TVNewser | 12301 | 4427 |
| 93 | @guardiannews | The Guardian | 75198 | 4665 |
| 94 | @yahoonews | Yahoo! News | 37154 | 4668 |
| 95 | @seedmag | Seed Magazine | 9898 | 4696 |
| 96 | @tvguide | TV Guide | 586240 | 4757 |
| 97 | @travlandleisure | Travel + Leisure | 84029 | 4767 |
| 98 | @newyorkpost | New York Post | 43334 | 4790 |
| 99 | @discovermag | DISCOVER Magazine | 71913 | 4816 |
| 100 | @sciencenewsorg | Science News | 75665 | 4888 |